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Rerum® Protocol North America

The ultimate Macrophage Activating Factor (MAF)
All natural Dietary Supplement well above and beyond blood-derived GcMAF!

Rerum Protocol For Disease Free Long Life North America

Rerum®is Macrophage Activating Factor (MAF)

Strengthening the “Innate Immune System”

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Expression and Function of Macrophages

Which Are Activated by Rerum®

Rerum Protocol For Disease Free Long Life North America

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Rerum®is Macrophage Activating Factor (MAF)

Strengthening the “Innate Immune System”

Inventor, Prof. Dr. Marco Ruggiero

MD, Clinical Radiology; PhD, Molecular Biology

  • The Science: A number of other research groups, have discovered that there are different phenotypes in humans, thus leading to different coding regions for amino acids for the human Vitamin-D binding protein (DBP). This is due to allelic differences: one group of GC polymorphism, the GC1 group, has a threonine residue whilst the GC2 group has a lysine residue.
  • The possible genetic alternatives in GC1 and GC2 groups on the same genetic locus lead to completely new conclusions being drawn about GcMAF being the only protein-derived MAF (DBP) in healthy human bodies. If there are humans without a threonine coding for GcMAF, in other words subjects homozygous for GC2 and therefore with a lysine coding instead, they would not have a single molecule of GcMAF in their bodies; therefore, their immune system would be weak and they would have a much higher risk of developing cancer. But this is not the case.
  • On the other hand, studies around the world by many researchers have demonstrated, amongst other things, that the activation of macrophages produces pro-immunogenic, anti-inflammatory, neuro-protective and even anti-cancer/anti-angiogenetic effects.
  • The efficiency of such an immune modulation is based on the molecular structure of GcMAF, which contains vitamin D and fatty acids, in particular oleic acid and chondroitin sulfate. The effects observed in GcMAF are solely due to its function as a carrier protein. The GcProtein itself has no effect per se; it only serves to carry the molecules endowed with all the effects erroneously attributed to GcMAF.
  • And what about oleic acid and vitamin D? Could other effects previously and erroneously attributed to GcMAF be due to vitamin D and oleic acid instead? Indeed, numerous studies now show the benefits of these substances in different diseases.
  • Based on this new understanding our 4th., generation “Dietary Supplement” has been reconstituted based on all the effects described and even boost the power of the aforementioned structure by designing the proper Macrophage Activating Factor: as Rerum®. This is a new generation MAF without the GcMAF protein itself. In the newly developed Rerum®, the protein backbone is replaced by chondroitin sulfate.
  • While GcMAF from human blood protein only has one chemical bond for certain moieties, chondroitin has more than 50 moieties for N-Acetylgalctosamine (GalNac). Rerum® demonstrates the effects attributed to GcMAF, and even goes so far as to also show those properties that have long been linked to chondroitin sulfate.

 

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  • What is Different?
  • Rerum® is not derived from blood and therefore not affected by any of the problems afflicting blood-derived  proteins.
  • Rerum® is not digested by stomach acid or by stomach proteases since it is not a protein; on the contrary, its bioavailability is increased by digestion.  
  • Rerum® does not require any particular care for storage and shipping, such as special cooling or even freezing.  
  • Rerum® does not induce allergic reactions since glycosaminoglycans are notoriously non-allergenic.  
  • Rerum® is a bona fide dietary supplement since it is composed of well-known dietary supplements that have been in use for decades.  
  • Rerum® is inherently safe since it is composed of components that have been used for decades in human medicine. Chondroitin sulfate, vitamin D and oleic acid are regulated substances in the U.S. as dietary supplements, approved by the Food and Drug Administration.  
  • In Europe, chondroitin sulfate formulations are approved as drugs with evidenced efficacy and safety demonstrated by clinical trials.  
  • Rerum® is extremely bioavailable at variance with long proteins such as GcMAF.   This is due to the inherent flexibility of the chondroitin sulfate backbone and the presence of a fatty acid, oleic acid.   Thanks to this unique combination, Rerum® is rapidly absorbed via a variety of routes and is immediately bioavailable.  
  • Rerum® is nanosized.   This means that its contact surface is about 1,000 times wider than that of a long protein such as GcMAF.   Rerum® is therefore able to reach a much larger number of targets in the human body.  
  • With the invention of Rerum®, we finally have the one and only, real, safe Macrophage Activating Factor (MAF).  
  • Rerum® is manufactured in a state-of-the art GMP-certified facility in Germany. Rerum® is available in sterile vials for oral intake (alternative: adapplicator).
  • Rerum® is in the process for approval by Health Canada and FDA in the USA.
  • Rerum® shall be shipment ready by early 2016. As well it will also be available for administration to patients as part of Health & Wellness treatment and protocols at our facilities in Toronto at our Integrative Health Center North America with boots on the ground across the USA, Hawaii, Puerto Rico, and Mexico.

 

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Rerum® is Macrophage Activating Factor (MAF)

Strengthening the “Innate Immune System”

Integrative Health Center North America

Canada – USA – Europe

Rerum Protocol For Disease Free Long Life North America

 

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Rerum Ketogenic Diet

DISEASE PREVENTATIVE KETOGENIC DIET

We have re-designed the Ketogenic Diet to slow the progression of disease. Any disease, for those who are diagnosed and to immunize the body against disease, any disease, for those who are not diagnosed. Modified Ketogenic Diet implemented accurately can produce optimum results by way of weight loss, increased energy, and increased body immunity against disease, any disease.   Modified Ketogenic Diet supported by proprietary supplements such as Bravo Probiotics cause the human body cells operate at optimum levels where such an environment is not conducive for any disease from taking hold in the body.

When we look to a diet for answers, any diet,  it usually has to do with a desire to lose some weight, and to look and feel better about ourselves and the image we portray.

Rerum Ketogenic DietBut which diet should we follow, and much more importantly, why? Does the explanation associated with a particular diet make sense? Is there evidence-based research or clinical trials in the medical community to support this or that dietary strategy?

There are thousands of diets, most of which pivot of a reduced caloric intake, and pay little attention to anything else. What about vitamins (vital amines), essential amino acids and trace minerals, all of which the body cannot produce on its own, and needs your help to supply, through diet. Without these in reasonable quantity, serious injury and even death can result.

In history, many different diets have evolved, in which vitamin C, ascorbic acid) had been neglected. According to Linus Pauling (and more recently, the medical community at large), 2 time Nobel prize winner (one for peace, and the other in chemistry for the development of the electronegativity chart of the elements), vitamin C is a powerful anti-oxidant, which, if taken in mega doses, can significantly reduce the incidence of cancer through its activity on free radicals in the body.

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Rerum Ketogenic Diet

However, among many other roles of ascorbic acid, the most important is its involvement as a cofactor in the production and strengthening of collagen.

Collagen is the most abundant protein in the human body. It is a protein composed of 1042 amino acids, and is arranged in a triple helix, which is thoroughly cross-linked for strength. Essentially, it represents the scaffolding which holds the whole body together.

It is found in the bones, muscles, skin, tendons and blood vessels, and provides strength and structure.

Rerum Ketogenic Diet

One of the amino acids in the structure of collagen is Proline. In most cases, the proline residue must be hydroxylated, in order that further hydrogen bonding can occur with the neighboring chains. This hydroxylation is catalyzed by an enzyme called prolyl hydroxylase, and ascorbic acid is a cofactor in this reaction. Without vitamin C, in fact, this reaction cannot occur, and the added inter-chain hydrogen bonds will not develop, causing the collagen fibers being produced to be defective.

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Rerum Ketogenic Diet

In fact, collagen synthesized in absence of vitamin C will denature at 24oc, instead of the 39oc in normal collagen. Since humans have a normal core temperature of 37oc, this poses a real problem. Bones become brittle, joints faulty, blood vessels unable to hold blood, skin ulcerates, teeth can no longer be held and will fall out, and ultimately, if not rectified, death will ensue. The lack of structural integrity of collagen in situ, is the basis of a disease called Scurvy, which, thankfully, is seldom seen any longer.

 

EAT FAT -YOU MUST EAT FAT

Until very recently, food biochemistry has been quite a mystery, even for physicians. Some generalizations have been made – ‘don’t eat saturated fats… they are not good for you’. This made sense for a physician, and it seems to make sense for most of us. There is some evidence to support a claim like this, but with the incomplete understanding of what happens to a chemical when it enters the GI tract, and the limited knowledge of cross reactions in the body, can we claim with absolute confidence, that consumption of a saturated fat is detrimental to our health. Perhaps saturated fat is harmful in the presence of other nutritional chemicals, and is, in fact, very good for us in the absence of that other nutrient. Perhaps backing up a little to look at the bigger picture might help.

The Rerum Diet is a high fat, moderate protein diet which involves no carbs, adequate supplements and a lot of water. In this diet, fish, fish oils, poultry, some red meats, butter, eggs, cheese, avocados, coconut oil, MCT oils, sausages, and some types of nuts (low quantity) and occasionally tofu, are some examples of foods which are in keeping with this diet.

Rerum Ketogenic Diet

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Per Marcel M. Cohen, P.Eng., (Canada) the originator of No Carbs Rerum Diet where the key is the lack of carbs – no carbs! To understand the basis of this approach, a few basics of metabolism need to be reviewed.

Any carbohydrate which is ingested, will be broken down through various means into their basic subunits, glucose, once absorbed and brought into cells, will undergo conversion, through glycolysis and the Krebs cycle, to produce an abundance of adenosine tri-phosphate (ATP), a high energy molecule which is the usable currency of energy in our bodies. But, if the energy is not utilized, it must be stored.

Glucose is a hydrophilic molecule. Storing glucose in general is difficult because of its water solubility and its relatively low energy properties (4 calories per gram carbs) compared with fat (9 calories per gram), and would require a large amount of space. Therefore, unused energy is converted into fat through lipogenesis.

Rerum Ketogenic Diet

Figure 1 – Excess calories convert into fat

 

Decades later in life, we may decide that a bit too much fat has been stored, and something must be done to shed those unwanted pounds.

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In the absence of carbohydrates, the body is forced to use alternative sources of fuel in order to produce ATP. The Rerum diet, which encourages the use of high fat (certain types) and proteins, causes our metabolism to shift in favour of ketosis.

Ketosis refers to a metabolic state in the body where there is not enough glucose available to use as energy, so a switch occurs where molecules called ketones are generated during fat metabolism, and used for most of the body’s energy. Ketones can be used for energy, and have a special property – they can be used instead of glucose for most of the energy needed in the brain, where fatty acids can’t be used. Also, many tissues of the body prefer to use ketones, in that they will use them as their primary source of fuel when available (myocardium for example).

Ketone bodies are formed by ketogenesis in the absence of glucose and when liver glycogen stores are depleted (or from metabolizing medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder.

Longer-term ketosis may result from fasting or staying on a no carb diet, and deliberately induced ketosis serves as a medical intervention for uncontrollable epilepsy, and has shown success with other neurological conditions.

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In glycolysis, higher levels of insulin promote storage of body fat and block the release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is often referred to as the body’s fat burning mode. This is the advantage of the Rerum Diet.

The fact is, in a diet rich in carbs, stored fat will be much more difficult to release, if not impossible in many circumstances. Using our diet, even for general health, I unintentionally lost 16 pounds (my BMI of 27 is at the borderline, and I had not intended to lose weight) in less 2 weeks. Incidentally, I have also had environmental allergies for the past 28 years, which have completely disappeared in my first week on the Rerum Diet.

But are there any other benefits to the Rerum Diet?  Absolutely.

Research shows glucose fuels and even causes cancer cells. For greater clarity,

  1. Scientists have actually shown in the Journal of Clinical Investigation January 2014, glucose can cause cancer via not one, but two biochemical pathways2. There are at least six research studies in the last few years which show that:
    a. People with the highest levels of blood glucose develop more cancers
    b. People with cancer, who also have the highest blood levels of glucose, survive least.
  2. Johns Hopkins scientists have shown starving patients of sugar is crucial in colorectal cancer.
  3. A June 2013 paper in the European Journal of Clinical Nutrition listed the following conditions as possibly being helped by ketogenic diets:

Strong Evidence

Emerging Evidence (some evidence with more research in progress)

  • Neurological Diseases other than epilepsy, including Parkinson’s Disease, Alzheimer’s Disease, narcolepsy, brain trauma, and amyotrophic lateral sclerosis
  • Polycystic Ovarian Syndrome
  • Acne
  • Some types of cancer (especially, some types of brain cancer)
  • Autism

Rerum Ketogenic Diet

Swedish Study Shows More Cancer in People With Higher Blood Sugar, Regardless of Diabetes
WebMD Health News

Feb. 27, 2007 — Women with high blood sugar may be more likely to develop cancer, even if they don’t have diabetes, a Swedish study shows.

High blood sugar (hyperglycemia) wasn’t tied to men’s overall cancer risk.

But when researchers looked at specific types of cancer, they found that both men and women with the highest blood sugar levels were more likely to have pancreatic cancer, urinary tract cancer, and malignant melanoma (the most deadly type of skin cancer) than those with the lowest blood sugar levels.

Keeping blood sugar levels within the normal range may reduce cancer risk, write the researchers, who included Par Stattin, MD, PhD, of Sweden’s Umea University Hospital.

For the study, Stattin’s team conducted a study of 64,600 non-smoker, non-diabetic residents in northern Sweden when they were 40, 50, or 60 years of age.

Upon enrolling, the participants underwent fasting glucose and glucose tolerance tests, with 85% and 92% normal respectively.

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Study’s Results

The researchers followed participants for eight years, on average.

Overall, women with the highest blood sugar levels upon joining the study were more likely to be diagnosed with cancer before its end, compared with women with the lowest blood sugar levels.

Also, endometrial carcinoma (endometrial cancer) was more common in women with the highest blood sugar levels, compared with those with the lowest blood sugar levels.

Breast cancer was more common for women younger than 49 with high blood sugar levels, compared with those with the lowest blood sugar levels, the study also shows.

The results held when researchers considered other factors, such as participants’ weight and age.

Their study appears in the March, 2007 edition of Diabetes Care

In summary, the Rerum Diet is safe, it forces an alternate metabolic pathway to energy production that the vast majority of cell in the body can use, while allowing fat stores to be mobilized and weight to be lost confidently. Rerum Diet contributes to many other ailments as illustrated.

Please look for upcoming reports on Rerum Protocol and the Immune System.

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Cathy Cohen Wellness Center – USA

The Cathy Cohen Wellness Center  is relocating to Florida / USA.  To an an innovative facility in Tampa Florida.  cathyThe clinic offers a multidisciplinary approach to health and wellness. We offer customized wellness packages, directional supplementation, proprietary diet strategies, detox regimes, and much more, in a safe, professional, and comfortable environment.

The center is open 6 days a week. Weekend access to the suite is limited, so please check with the nurse or reception if Sunday arrangements need to be made.

This center will provide access to state-of-the-art supplements and dietary plans and other approaches, which are not covered under the OHIP/Canada schedule. Our clinical services exceed national clinical quality standards.

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What do we offer?

  1. Wellness packages to help with general health or specific problems
  2. Multi-format Detoxification
  3. Nutritional counselling and dietary approaches to weight loss and well being
  4. Immune re-sensitization and amplification
  5. Supplementation for multiple end-points

In the world today, the two main causes of premature death are heart disease and cancer. There are presently 15-20 million cancer cases in the world today, up to 5 million of those being unaware of their disease. These numbers are on the rise. In the US alone, in 2014, there were 600,000 cancer related deaths, and 1.7 million new cases.

In men, the number one cancer is prostate, present in 43% of male cancer patients. In females, 41% of known cancers are breast tumors. There are now more than 200 known types of cancer in humans, the vast majority being fat-soluble in nature.

The standard allopathic approach is to employ chemotherapeutic regimes to treat tumors. Unfortunately, these harsh drugs are given by IV or Hickman line administration, so the entire body is exposed to these poisons, and share in their effects. The truth is that the medical community is completely uncertain of the results of the administration of any chemo drug, and hopes, collectively, that the drug will kill the tumor before it kills the patient.

Is there a set of supplements which might help to shield the effects of chemotherapeutic agents on the rest of the body? Yes there is.

For questions or to make an appointment to see one of our knowledgeable technologists or nurses, please fill the form below. Initial consultation is recommended for us to collect some information as to your history or circumstances, and to begin constructing a wellness plan tailored to you needs and objectives.

 

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